Nature

Activation of PKA and phosphorylation of sodium-dependent vitamin C transporter 2 by prostaglandin E2 promote osteoblast-like differentiation in MC3T3-E1 cells

Sodium-dependent vitamin C transporter (SVCT) 2-mediated L-ascorbic acid (AA) uptake is required in osteoblast-like differentiation of MC3T3-E1 cells, and prostaglandin E2 (PGE2) is among the most ...
Nature

Protein kinase A activation by the anti-cancer drugs ABT-737 and thymoquinone is caspase-3-dependent and correlates with platelet inhibition and apoptosis

Chemotherapy-induced thrombocytopenia is a common bleeding risk in cancer patients and limits chemotherapy dose and frequency. Recent data from mouse and human platelets revealed that activation of ...
EurekAlert!

Phosphorylation and dephosphorylation enzyme groups regulate sleep and wakefulness in mammals

Recent research has observed that chemical modifications called phosphorylation of various proteins *1) in brain neurons dynamically regulates in controlling sleep and wakefulness. On the other hand, ...
EurekAlert!

Spatiotemporal PKA Activation After Glutamate Uncaging at a Single Spine (IMAGE)

Top: Fluorescence lifetime images of AKARet-cyto in a secondary dendrite of a CA1 pyramidal neuron during sLTP. Bottom: PKA activation along the dendrite at various distances from the stimulated spine ...
Phys.org

Enzyme study sheds light on the molecular mechanism behind 'sleepiness'

Recent research has observed that chemical modifications called phosphorylation of proteins in brain neurons dynamically regulate sleep and wakefulness. But the protein kinases that suppress sleep and ...