A team at ETH Zurich developed a new peptide-based organocatalyst that handles macrocycle formation from start to finish.

Spiroketals are privileged substructures found in numerous natural products. Even relatively simple spiroketals exhibit a range of biological activities. In more complex structures, spiroketals often ...

Cross-coupling reactions typically rely on the use of transition metal catalysis. However, although achieving this process using metal-free organocatalysts is highly challenging, it could offer unique ...

A quote from Rudolph Buchheim, an experimental pharmacologist who lived from 1820 to 1879, summarizes the nature and importance of studies in drug metabolism, including the pharmacokinetics and ...

Three domains (HSA DOM I, II and III) were expressed in Pichia pastoris GS115 cells. Blue Sepharose 6 Fast Flow was employed to purify the recombinant HSA domains. The binding properties of the ...