In this issue, Eijsvogel et al. share the results of a phase 1 study that investigated the safety, tolerability and immunogenicity of UB-312 (an immunotherapeutic that targets pathological α-synuclein ...

In low- and middle-income countries (LMICs), adolescents have limited access to healthcare. A study in urban Zimbabwe demonstrated that routine check-up visits integrated within existing school and ...

In this issue, Zou and colleagues present a multimodal artificial intelligence model that extracts images and their associated descriptions from pathology-related tweets, and show its potential for ...

Obesity and associated complications can be managed by obesity medications, prompting the revision of criteria for the diagnosis and staging of this disease.

Preclinical and initial human studies suggest that glucagon-like peptide-1 receptor agonists may be promising treatments for alcohol use disorder, but existing approved treatments should be used until ...

Premature infants often undergo repeated episodes of hypoxia and can develop a condition called encephalopathy of prematurity with long-term neurodevelopmental impairments. In this issue, Paşca et al.

Two phase 1 studies report promising outcomes with chimeric antigen receptor (CAR) T cell therapies in patients with systemic lupus erythematosus, but the next stage of development must address key ...

Stockpiled A(H5N1) influenza vaccines made using viruses from the mid-2000s stimulate antibodies that cross-react with current strains, despite being separated by 20 years of viral evolution — ...

Germline predisposition plays a major part in myelodysplastic syndromes in children. Sahoo et al. report that germline mutations in the genes SAMD9 and SAMD9L account for 8% of pediatric ...

In this issue, Widschwendter and colleagues establish that screening of cervical cancer using a DNA methylation-based triage showed better performance than cytology in the detection of prevalent ...

Developed through systematic review and expert consensus, the REP-EQUITY toolkit provides a seven-step guide for investigators to facilitate representative and equitable recruitment into clinical ...

A systematic review and meta-analysis of studies covering 66 countries reported wide-ranging maternal, fetal and neonatal health harms associated with heat exposure, including increased risks of ...