The GTPase switch is a versatile molecular device used by many proteins, such as the small GTPases, to regulate an astounding number of functions. Although the basics of the guanine nucleotide cycle ...

Figure 1: Domain structure of dynamin showing mutants of the GTPase domain. Figure 2: Uptake of biotinylated transferrin (green staining) into COS-7 fibroblasts, transiently overexpressing dynamin or ...

For most of us who haven’t entirely slept through biology classes, it’s probably no secret that ATP (adenosine triphosphate) is the compound which provides the energy needed for us to move our muscles ...

The Transcreener GTPase Assay Kit relies on direct detection of GDP produced by GTPases during GTP hydrolysis. The direct detection approach is a novel method to quantify activity of GTPases and their ...

Erasca Inc. has described GTPase KRAS (G12D mutant) and/or KRAS (G12V mutant) inhibitors reported to be useful for the treatment of cancer.

Kumquat Biosciences Inc. has disclosed son of sevenless homolog 1 (SOS1)/GTPase KRAS (G12C mutant) interaction inhibitors reported to be useful for the treatment of cancer.

Although there are more than 150 guanosine triphosphate (GTP)–binding proteins, or GTPases, only the GTPase KRas G12C has proved susceptible to small-molecule drugs. That’s because it’s tough to find ...

GPCRs are by far the most extensively validated class of therapeutic targets, and there remains tremendous potential for targeting new receptors and their downstream effectors. GPCRs at the cell ...